James G Keck Selected Research

gamma-Glu-S-BzCys-PhGly diethyl ester (T.199)

6/2009	Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome.
5/2009	Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome.

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James G Keck Research Topics

Disease

8	Neoplasms (Cancer) 01/2020 - 05/2003
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 11/2009
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 06/2009 - 05/2009
1	Cytokine Release Syndrome 01/2020
1	Autoimmune Diseases (Autoimmune Disease) 01/2020
1	Hypersensitivity (Allergy) 01/2020
1	Fever (Fevers) 01/2020
1	Triple Negative Breast Neoplasms 01/2018
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 01/2018
1	Ebola Hemorrhagic Fever 10/2016
1	Stomatitis 07/2010
1	Ovarian Neoplasms (Ovarian Cancer) 07/2010
1	Glioma (Gliomas) 10/2009
1	Leukemia 10/2009
1	Prostatic Neoplasms (Prostate Cancer) 10/2009
1	Diabetes Complications 08/2004
1	Insulin Resistance 08/2004

Drug/Important Bio-Agent (IBA)

3	ProdrugsIBA 06/2009 - 06/2004
3	Glutathione (Reduced Glutathione)IBA 06/2009 - 05/2003
3	Glutathione Transferase (Glutathione S-Transferase)IBA 06/2009 - 05/2003
2	DNA (Deoxyribonucleic Acid)IBA 05/2015 - 10/2009
2	gamma-Glu-S-BzCys-PhGly diethyl ester (T.199)IBA 06/2009 - 05/2009
2	TER 286 (TLK286)IBA 06/2004 - 05/2003
1	Monoclonal AntibodiesIBA 01/2020
1	CytokinesIBA 01/2020
1	AZ5104IBA 01/2018
1	pembrolizumabIBA 01/2018
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2018
1	Programmed Cell Death 1 ReceptorIBA 01/2018
1	osimertinibIBA 01/2018
1	Viral AntigensIBA 10/2016
1	Biomarkers (Surrogate Marker)IBA 05/2015
1	Pharmaceutical PreparationsIBA 05/2015
1	liposomal doxorubicin (Doxil)FDA Link 07/2010
1	PlatinumIBA 07/2010
1	1-dodecylpyridoxal (PLD)IBA 07/2010
1	Carboplatin (JM8)FDA LinkGeneric 11/2009
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2009
1	TLK58747IBA 10/2009
1	AcidsIBA 10/2009
1	TabletsIBA 06/2009
1	Liposomes (Liposome)IBA 05/2009
1	HIV Protease InhibitorsIBA 08/2004
1	TLK 19781IBA 08/2004
1	Protease Inhibitors (Protease Inhibitor)IBA 08/2004
1	Insulin ReceptorIBA 08/2004

Therapy/Procedure

6	Therapeutics 01/2020 - 06/2004
2	Immunotherapy 01/2020 - 01/2018
1	Transplantation 01/2020
1	Drug Therapy (Chemotherapy) 01/2018